Dosing & Level History

Enter time relative to start (h). Leave dose blank for levels.


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1. TIME: Hours from start (0, 12, 24...)

2. DOSE: Amount in mg

3. DURATION: Infusion time (usually 1-2h)

4. LEVEL: Observed concentration (mg/L)


Parameters


                

AUC24 (mg·h/L)

Est. Trough (mg/L)

Est. Peak (mg/L)

CrCL used (mL/min)



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📚 Model References

  • Goti et al: “Hospitalized patients with and without hemodialysis have similar vancomycin clearance.' Ther Drug Monit. 2018.
  • Thomson et al: 'Population pharmacokinetics and dosing of vancomycin in critically ill patients.' J Antimicrob Chemother. 2009.
  • Hughes et al: 'A hybrid machine learning/pharmacokinetic approach outperforms maximum a posteriori Bayesian estimation by selectively flattening model priors' CPT Pharmacometrics Syst Pharmacol 2021.
  • Buelga et al: Population pharmacokinetic analysis of vancomycin in patients with hematological malignancies.' Antimicrob Agents Chemother. 2005.
  • Hughes et al: Developing Parametric and Nonparametric Models for Model-Informed Precision Dosing: A Quality Improvement Effort in Vancomycin for Patients With Obesity.' Ther Drug Monit. 2024

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Last Updated: December 2025

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